The impact of anionic polymers on gene delivery: how composition and assembly help evading the toxicity-efficiency dilemma

The impact of anionic polymers on gene delivery: how composition and assembly help evading the toxicity-efficiency dilemma

Abstract Cationic polymers have been widely studied for non-viral gene delivery due to their ability to bind genetic material and to interact with cellular membranes. However, their charged nature carries the risk of increased cytotoxicity and interaction with serum proteins, limiting their potentia...

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Bibliographic Details
Main Authors: Friederike Richter, Katharina Leer, Liam Martin, Prosper Mapfumo, Jana I. Solomun, Maren T. Kuchenbrod, Stephanie Hoeppener, Johannes C. Brendel, Anja Traeger
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Nanobiotechnology
Subjects:
Gene delivery
Cationic polymer
Micelle
Transfection
Anionic polymer
Shielding
Online Access:https://doi.org/10.1186/s12951-021-00994-2

Internet

https://doi.org/10.1186/s12951-021-00994-2

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