Oxygen Sensitivity of Reporter Genes: Implications for Preclinical Imaging of Tumor Hypoxia

Reporter gene techniques have been applied toward studying the physiologic phenomena associated with tumor hypoxia, a negative prognostic indicator. The purpose of this study was to assess the potential adverse effects of hypoxic conditions on the effectiveness of four commonly used reporter genes:...

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Bibliographic Details
Main Authors: Ivana Cecic, Denise A. Chan, Patrick D. Sutphin, Pritha Ray, Sanjiv Sam Gambhir, Amato J. Giaccia, Edward E. Graves
Format: Article
Language:English
Published: Hindawi - SAGE Publishing 2007-07-01
Series:Molecular Imaging
Online Access:https://doi.org/10.2310/7290.2007.00017