Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides.

Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides.

Microbial natural products constitute a wide variety of chemical compounds, many which can have antibiotic, antiviral, or anticancer properties that make them interesting for clinical purposes. Natural product classes include polyketides (PKs), nonribosomal peptides (NRPs), and ribosomally synthesiz...

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Bibliographic Details
Main Authors: Alexander M Kloosterman, Peter Cimermancic, Somayah S Elsayed, Chao Du, Michalis Hadjithomas, Mohamed S Donia, Michael A Fischbach, Gilles P van Wezel, Marnix H Medema
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-12-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001026

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https://doi.org/10.1371/journal.pbio.3001026

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