Targeting murine leukemic stem cells by antibody functionalized mesoporous silica nanoparticles

Abstract Acute leukemia is initiated and maintained by leukemia stem cells (LSCs) and therefore there is great interest to develop innovative therapeutic approaches which target LSCs. Here we show that mesoporous silica nanoparticles (MSNs) functionalized with succinic anhydride, tagged with an anti...

Full description

Bibliographic Details
Main Authors: Tamoghna Mandal, Michaela Beck, Nicole Kirsten, Mika Lindén, Christian Buske
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-18932-4