Kidney-specific expression of GFP by in-utero delivery of pseudotyped adeno-associated virus 9

Gene therapy targeting of kidneys has been largely unsuccessful. Recently, a recombinant adeno-associated virus (rAAV) vector was used to target adult mouse kidneys. Our hypothesis is that a pseudotyped rAAV 2/9 vector can produce fetal kidney-specific expression of the green fluorescent protein (GF...

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Bibliographic Details
Main Authors: Jason L Picconi, Melissa A Muff-Luett, Di Wu, Erik Bunchman, Franz Schaefer, Patrick D Brophy
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050116300791