Effect of pH on the Interaction of Gold Nanoparticles with DNA and Application in the Detection of Human p53 Gene Mutation

Effect of pH on the Interaction of Gold Nanoparticles with DNA and Application in the Detection of Human p53 Gene Mutation

<p>Abstract</p> <p>Gold nanoparticles (GNPs) are widely used to detect DNA. We studied the effect of pH on the assembly/disassembly of single-stranded DNA functionalized GNPs. Based on the different binding affinities of DNA to GNPs, we present a simple and fast way that uses HCl t...

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Bibliographic Details
Main Authors: Sun Liping, Zhang Zhaowu, Wang Shuang, Zhang Jianfeng, Li Hui, Ren Lei, Weng Jian, Zhang Qiqing
Format: Article
Language:English
Published: SpringerOpen 2008-01-01
Series:Nanoscale Research Letters
Subjects:
Single-stranded DNA
HCl
Gold nanoparticles
p53
Mutation
Online Access:http://dx.doi.org/10.1007/s11671-008-9228-z

Internet

http://dx.doi.org/10.1007/s11671-008-9228-z

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