Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization

Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization

Sperm-egg fusion requires the interaction between IZUMO1 on the sperm and JUNO on the egg. Here, the authors report the crystal structure of mouse JUNO, and use it to explain its lack of binding to folate, along with in vivofunctional analyses.

Bibliographic Details
Main Authors: Kazuki Kato, Yuhkoh Satouh, Hiroshi Nishimasu, Arisa Kurabayashi, Junko Morita, Yoshitaka Fujihara, Asami Oji, Ryuichiro Ishitani, Masahito Ikawa, Osamu Nureki
Format: Article
Language:English
Published: Nature Publishing Group 2016-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12198

Internet

https://doi.org/10.1038/ncomms12198

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