Liquid biopsy using the supernatant of a pleural effusion for EGFR genotyping in pulmonary adenocarcinoma patients: a comparison between cell-free DNA and extracellular vesicle-derived DNA

Liquid biopsy using the supernatant of a pleural effusion for EGFR genotyping in pulmonary adenocarcinoma patients: a comparison between cell-free DNA and extracellular vesicle-derived DNA

Abstract Background EGFR genotyping in pulmonary adenocarcinoma patients who develop pleural effusions is mostly performed using cytology or cell block slides with low sensitivity. Liquid biopsy using the supernatant of pleural effusions may be more effective because they contain many components rel...

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Bibliographic Details
Main Authors: Jong Sik Lee, Jae Young Hur, In Ae Kim, Hee Joung Kim, Chang Min Choi, Jae Chol Lee, Wan Seop Kim, Kye Young Lee
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Cancer
Subjects:
Pleural effusion
Pulmonary adenocarcinoma
EGFR mutation
Extracellular vesicles
Liquid biopsy
Online Access:http://link.springer.com/article/10.1186/s12885-018-5138-3

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http://link.springer.com/article/10.1186/s12885-018-5138-3

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