Frataxin knockdown in human astrocytes triggers cell death and the release of factors that cause neuronal toxicity

Frataxin knockdown in human astrocytes triggers cell death and the release of factors that cause neuronal toxicity

Friedreich's ataxia (FA) is a recessive, predominantly neurodegenerative disorder caused in most cases by mutations in the first intron of the frataxin (FXN) gene. This mutation drives the expansion of a homozygous GAA repeat that results in decreased levels of FXN transcription and frataxin pr...

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Bibliographic Details
Main Authors: Frida Loría, Javier Díaz-Nido
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Neurobiology of Disease
Subjects:
Friedreich's ataxia
Astrocytes
Cell death
Apoptosis
Neurotoxicity
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611400388X

Internet

http://www.sciencedirect.com/science/article/pii/S096999611400388X

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