A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans.

A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans.

Candida sp. are opportunistic fungal pathogens that colonize the skin and oral cavity and, when overgrown under permissive conditions, cause inflammation and disease. Previously, we identified a central role for the NLRP3 inflammasome in regulating IL-1β production and resistance to dissemination fr...

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Bibliographic Details
Main Authors: Jeffrey Tomalka, Sandhya Ganesan, Elaheh Azodi, Krupen Patel, Parth Majmudar, Brian A Hall, Katherine A Fitzgerald, Amy G Hise
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-12-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3234225?pdf=render

Internet

http://europepmc.org/articles/PMC3234225?pdf=render

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