Hybrides of Alkaloid Lappaconitine with Pyrimidine Motif on the Anthranilic Acid Moiety: Design, Synthesis, and Investigation of Antinociceptive Potency

Hybrides of Alkaloid Lappaconitine with Pyrimidine Motif on the Anthranilic Acid Moiety: Design, Synthesis, and Investigation of Antinociceptive Potency

Convenient and efficient routes to construct hybrid molecules containing diterpene alkaloid lappaconitine and pyrimidine fragments are reported. One route takes place via first converting of lappaconitine to 1-ethynyl-lappaconitine, followed by the Sonogashira cross-coupling-cyclocondensation sequen...

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Bibliographic Details
Main Authors: Kirill P. Cheremnykh, Victor A. Savelyev, Sergey A. Borisov, Igor D. Ivanov, Dmitry S. Baev, Tatyana G. Tolstikova, Valentin A. Vavilin, Elvira E. Shults
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
cross-coupling reaction
multi-component synthesis
alkaloids
lappaconitine
pyrimidine
analgesic activity
Online Access:https://www.mdpi.com/1420-3049/25/23/5578

Internet

https://www.mdpi.com/1420-3049/25/23/5578

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