HIV Nef and Antiretroviral Therapy Have an Inhibitory Effect on Autophagy in Human Astrocytes that May Contribute to HIV-Associated Neurocognitive Disorders

HIV Nef and Antiretroviral Therapy Have an Inhibitory Effect on Autophagy in Human Astrocytes that May Contribute to HIV-Associated Neurocognitive Disorders

A significant number of people living with HIV (PLWH) develop HIV-associated neurocognitive disorders (HAND) despite highly effective antiretroviral therapy (ART). Dysregulated macroautophagy (autophagy) is implicated in HAND pathogenesis. The viral protein Nef, expressed even with suppressive ART,...

Full description

Bibliographic Details
Main Authors: Laura Cheney, Hillary Guzik, Frank P. Macaluso, Fernando Macian, Ana Maria Cuervo, Joan W. Berman
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cells
Subjects:
HIV-associated neurocognitive disorders
Nef
astrocytes
antiretroviral therapy
autophagy
LC3
Online Access:https://www.mdpi.com/2073-4409/9/6/1426

Internet

https://www.mdpi.com/2073-4409/9/6/1426

Similar Items