SAMPLE SIZE DETERMINATION IN CLINICAL TRIALS BASED ON APPROXIMATION OF VARIANCE ESTIMATED FROM LIMITED PRIMARY OR PILOT STUDIES
In many casses the estimation of variance which is used to determine sample size in clinical trials, derives from limited primary or pilot studies in which number of samples is small. since in such casses the estimation of variance may be much far from the real variance, the size of samples is suspe...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2001-06-01
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| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://journals.mui.ac.ir/jrms/article/view/3464 |