Evolutionary analysis of the most polymorphic gene family in falciparum malaria [version 1; peer review: 1 approved, 2 approved with reservations]

The var gene family of the human malaria parasite Plasmodium falciparum encode proteins that are crucial determinants of both pathogenesis and immune evasion and are highly polymorphic. Here we have assembled nearly complete var gene repertoires from 2398 field isolates and analysed a normalised set...

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Bibliographic Details
Main Authors: Thomas D. Otto, Sammy A. Assefa, Ulrike Böhme, Mandy J. Sanders, Dominic Kwiatkowski, Pf3k consortium, Matt Berriman, Chris Newbold
Format: Article
Language:English
Published: Wellcome 2019-12-01
Series:Wellcome Open Research
Online Access:https://wellcomeopenresearch.org/articles/4-193/v1