Astrocyte-specific hypoxia-inducible factor 1 (HIF-1) does not disrupt the endothelial barrier during hypoxia in vitro

Astrocyte-specific hypoxia-inducible factor 1 (HIF-1) does not disrupt the endothelial barrier during hypoxia in vitro

Abstract Background Astrocytes (AC) are essential for brain homeostasis. Much data suggests that AC support and protect the vascular endothelium, but increasing evidence indicates that during injury conditions they may lose their supportive role resulting in endothelial cell activation and BBB distu...

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Bibliographic Details
Main Authors: Julia Baumann, Chih-Chieh Tsao, Sheng-Fu Huang, Max Gassmann, Omolara O. Ogunshola
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Fluids and Barriers of the CNS
Subjects:
Astrocytes
HIF-1
Endothelial activation
Barrier stability
Primary culture
In vitro BBB
Online Access:https://doi.org/10.1186/s12987-021-00247-2

Internet

https://doi.org/10.1186/s12987-021-00247-2

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