Maslinic Acid Enhances Docetaxel Response in Human Docetaxel-Resistant Triple Negative Breast Carcinoma MDA-MB-231 Cells via Regulating MELK-FoxM1-ABCB1 Signaling Cascade

Maslinic Acid Enhances Docetaxel Response in Human Docetaxel-Resistant Triple Negative Breast Carcinoma MDA-MB-231 Cells via Regulating MELK-FoxM1-ABCB1 Signaling Cascade

Docetaxel (DOC) is the most important chemotherapeutic drug for the treatment of triple negative breast cancer (TNBC); however, acquired drug resistance upon the long-term treatment limits its therapeutic effect. Maslinic acid (MA), a natural triterpene from Olea europaea L., attracts increasing int...

Full description

Bibliographic Details
Main Authors:	Ke Wang, Xue Zhu, Yongxiang Yin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-06-01
Series:	Frontiers in Pharmacology
Subjects:	triple negative breast cancer docetaxel resistance maslinic acid MELK-FoxM1-ABCB1 signaling cascade MDA-MB-231
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2020.00835/full

Similar Items

Erastin Reverses ABCB1-Mediated Docetaxel Resistance in Ovarian Cancer
by: Hai-Hong Zhou, et al.
Published: (2019-12-01)

Maternal Embryonic Leucine Zipper Kinase Promotes Tumor Growth and Metastasis via Stimulating FOXM1 Signaling in Esophageal Squamous Cell Carcinoma
by: Liang Chen, et al.
Published: (2020-01-01)

FOXM1 modulates docetaxel resistance in prostate cancer by regulating KIF20A
by: Hongbo Yu, et al.
Published: (2020-11-01)

MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells
by: Yubao Wang, et al.
Published: (2014-05-01)

The Effects on Proliferation of siRNA-Mediated GLS1 Inhibition in MDA-MB 231 Breast Cancer Cells
by: Sakine Akar, et al.
Published: (2019-12-01)

The effect of Quinacrine on MMP1 Gene Expression in MDA-MB 231 and MCF7 cell lines of breast cancer
by: Ganjkhanlou Z, et al.
Published: (2020-05-01)

ACSL1 Regulates TNFα-Induced GM-CSF Production by Breast Cancer MDA-MB-231 Cells
by: Reeby Thomas, et al.
Published: (2019-10-01)

Reprimo as a modulator of cell migration and invasion in the MDA-MB-231 breast cancer cell line
by: Kurt Buchegger, et al.

Polymorphism of CYP3A4 and ABCB1 genes increase the risk of neuropathy in breast cancer patients treated with paclitaxel and docetaxel
by: Kus T, et al.
Published: (2016-08-01)

LPS Induces GM-CSF Production by Breast Cancer MDA-MB-231 Cells via Long-Chain Acyl-CoA Synthetase 1
by: Fatema Al-Rashed, et al.
Published: (2020-10-01)

Cytotoxic effect of ICD-85 (venom-derived peptides) on MDA-MB-231 cell line
by: A Zare Mirakabadi, et al.
Published: (2008-01-01)

Synthesis of the C<sub>3</sub> and C<sub>1</sub> Constitutional Isomers of Trifluorosubphthalocyanine and Their Fluorescence within MDA-MB-231 Breast Tumor Cells
by: Rosemarie L. Calandrino, et al.
Published: (2019-10-01)

Comparative anticancer activities of Ficus carica and Ficus salicifolia latex in MDA-MB-231 cells
by: Fatma Mousa AlGhalban, et al.
Published: (2021-06-01)

In Vitro Cytotoxic Activity of Origanum vulgare L. on HCT-116 and MDA-MB-231 Cell Lines
by: Filip Grbović, et al.
Published: (2013-06-01)

Evaluation of anticancer potential of Bacopa monnieri L. against MCF-7 and MDA-MB 231 cell line
by: Md. Nasar Mallick, et al.
Published: (2015-01-01)

Effect of non-thermal atmospheric pressure plasma on MDA-MB-231 breast cancer cells
by: Ramin Mehrabifard, et al.
Published: (2017-09-01)

The selective anti-proliferative and pro-apoptotic effect of A. cherimola on MDA-MB-231 breast cancer cell line
by: Maria Younes, et al.
Published: (2020-11-01)

RU486 Metabolite Inhibits CCN1/Cyr61 Secretion by MDA-MB-231-Endothelial Adhesion
by: Suhong Yu, et al.
Published: (2019-11-01)

COX-2 expression correlation with invasion in human breast carcinomas and in cell line MDA-MB-231 in vitro
by: Gang-Ping Wang, et al.
Published: (2016-04-01)

Antitumor activity of arsenite in combination with tetrandrine against human breast cancer cell line MDA-MB-231 in vitro and in vivo
by: Bo Yuan, et al.
Published: (2018-08-01)

Enhancement of viability of radiosensitive (PBMC) and resistant (MDA-MB-231) clones in low-dose-rate cobalt-60 radiation therapy
by: Patrícia Lima Falcão, et al.
Published: (2015-06-01)

Extracts and components of Ficus carica leaves suppress survival, cell cycle, and migration of triple-negative breast cancer MDA-MB-231 cells
by: Zhang Y, et al.
Published: (2018-07-01)

Inhabitation Effect of Linoleic Acid, the Ingredient of Nigella sativa (Black Seed) on MDA-MB-231 and MCF-7 Human Breast Cancer Cells
by: Kourosh Hasanzadeh Ghahramanloo, et al.
Published: (2010-12-01)

PGRMC1 Inhibits Progesterone-Evoked Proliferation and Ca<sup>2+</sup> Entry Via STIM2 in MDA-MB-231 Cells
by: Carlos Cantonero, et al.
Published: (2020-10-01)

Accumulation of GD1α Ganglioside in MDA-MB-231 Breast Cancer Cells Expressing ST6GalNAc V
by: Sandy Vandermeersch, et al.
Published: (2015-04-01)

Analysis of Protein–Protein Interactions in MCF-7 and MDA-MB-231 Cell Lines Using Phthalic Acid Chemical
by: Shih-Shin Liang, et al.
Published: (2014-11-01)

Cytotoxicity of lanostane-type triterpenoids and ergosteroids isolated from Omphalia lapidescens on MDA-MB-231 and HGC-27 cells
by: Fei Liu, et al.
Published: (2019-10-01)

Polymorphismes et traitements néoadjuvants des cancers du sein : efficacité du docétaxel et polymorphisme d'ABCB1/MDR1
by: Gligorov, Joseph
Published: (2012)

Antiproliferative effect of gold(I) compound auranofin through inhibition of STAT3 and telomerase activity in MDA-MB 231 human breast cancer cells
by: Nam-Hoon Kim, et al.
Published: (2013-01-01)

A Relatively Small Gradient of Extracellular pH Directs Migration of MDA-MB-231 Cells In Vitro
by: Eiji Takahashi, et al.
Published: (2020-04-01)

The comparison of the apoptosis effects of titanium dioxide nanoparticles into MDA-MB-231 cell line in microgravity and gravity conditions
by: Azadeh Hekmat, et al.
Published: (2019-04-01)

Apoptosis Induced by 13-S-hydroxyoctadecadienoic acid in the Breast Cancer Cell Lines, MCF-7 and MDA-MB-231
by: Masoumeh Tavakoli-Yaraki, et al.
Published: (2013-04-01)

Involvement of the ERK/HIF-1α/EMT Pathway in XCL1-Induced Migration of MDA-MB-231 and SK-BR-3 Breast Cancer Cells
by: Ha Thi Thu Do, et al.
Published: (2021-12-01)

Bio-informatics and in Vitro Experiments Reveal the Mechanism of Schisandrin A Against MDA-MB-231 cells
by: Ling Chen, et al.
Published: (2021-09-01)

Extracellular Matrix Components Regulate Bone Sialoprotein Expression in MDA-MB-231 Breast Cancer Cells
by: Florian Keller, et al.
Published: (2021-05-01)

Mannoside-Modified Branched Gold Nanoparticles for Photothermal Therapy to MDA-MB-231 Cells
by: Han-Chen Lin, et al.
Published: (2020-04-01)

Invadopodia Formation is a Critical Step in Cancer Cell Invasion: The Effect of Passage Number on Invadopodia Formation in MDA-MB-231 Breast Cancer Cell Line
by: Hamad ALi Hamad, et al.
Published: (2018-12-01)

Lycorine inhibits MDA-MB-231 breast cancer cell proliferation, migration and invasion that are associated with Wnt/β-catenin signaling
by: Xia-Liang Chen
Published: (2018-06-01)

COX-2 expression correlation with invasion in human breast carcinomas and in cell line MDA-MB-231 <i>in vitro</i>
by: Gang-Ping Wang, et al.
Published: (2016-03-01)

Resveratrol Inhibits the Migration and Metastasis of MDA-MB-231 Human Breast Cancer by Reversing TGF-β1-Induced Epithelial-Mesenchymal Transition
by: Yang Sun, et al.
Published: (2019-03-01)