Maslinic Acid Enhances Docetaxel Response in Human Docetaxel-Resistant Triple Negative Breast Carcinoma MDA-MB-231 Cells via Regulating MELK-FoxM1-ABCB1 Signaling Cascade

Maslinic Acid Enhances Docetaxel Response in Human Docetaxel-Resistant Triple Negative Breast Carcinoma MDA-MB-231 Cells via Regulating MELK-FoxM1-ABCB1 Signaling Cascade

Docetaxel (DOC) is the most important chemotherapeutic drug for the treatment of triple negative breast cancer (TNBC); however, acquired drug resistance upon the long-term treatment limits its therapeutic effect. Maslinic acid (MA), a natural triterpene from Olea europaea L., attracts increasing int...

Full description

Bibliographic Details
Main Authors: Ke Wang, Xue Zhu, Yongxiang Yin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
triple negative breast cancer
docetaxel resistance
maslinic acid
MELK-FoxM1-ABCB1 signaling cascade
MDA-MB-231
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00835/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00835/full

Similar Items