Role of Cell-Penetrating Peptides in Intracellular Delivery of Peptide Nucleic Acids Targeting Hepadnaviral Replication

Role of Cell-Penetrating Peptides in Intracellular Delivery of Peptide Nucleic Acids Targeting Hepadnaviral Replication

Peptide nucleic acids (PNAs) are potentially attractive antisense agents against hepatitis B virus (HBV), although poor cellular uptake limits their therapeutic application. In the duck HBV (DHBV) model, we evaluated different cell-penetrating peptides (CPPs) for delivery to hepatocytes of a PNA-tar...

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Bibliographic Details
Main Authors: Bénédicte Ndeboko, Narayan Ramamurthy, Guy Joseph Lemamy, Catherine Jamard, Peter E. Nielsen, Lucyna Cova
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
antiviral therapy
peptide nucleic acid
PNA
cell-penetrating peptide
CPP
cell uptake
hepatitis B virus
HBV
duck hepatitis B virus
DHBV
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117302524

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http://www.sciencedirect.com/science/article/pii/S2162253117302524

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