Autologous Dendritic Cell Therapy in Mesothelioma Patients Enhances Frequencies of Peripheral CD4 T Cells Expressing HLA-DR, PD-1, or ICOS

Autologous Dendritic Cell Therapy in Mesothelioma Patients Enhances Frequencies of Peripheral CD4 T Cells Expressing HLA-DR, PD-1, or ICOS

Introduction: Malignant pleural mesothelioma (MPM) is a malignancy with a very poor prognosis for which new treatment options are urgently needed. We have previously shown that dendritic cell (DC) immunotherapy provides a clinically feasible treatment option. In the current study, we set out to asse...

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Bibliographic Details
Main Authors: Pauline L. de Goeje, Yarne Klaver, Margaretha E. H. Kaijen-Lambers, Anton W. Langerak, Heleen Vroman, André Kunert, Cor H. J. Lamers, Joachim G. J. V. Aerts, Reno Debets, Rudi W. Hendriks
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
dendritic cell vaccination
mesothelioma
immune monitoring
T lymphocytes
immunotherapy of cancer
inducible T-cell co-stimulator protein
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02034/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02034/full

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