APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease

APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease

Abstract Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for Alzheimer’s disease (AD), have yielded significant insights into the pathogenic mechanism. Among the three common coding variants, APOE*ε4 increases, whereas APOE*ε2 decreases the risk of late-onset AD compa...

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Bibliographic Details
Main Authors: Zonghua Li, Francis Shue, Na Zhao, Mitsuru Shinohara, Guojun Bu
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Molecular Neurodegeneration
Subjects:
Apolipoprotein E2
Alzheimer’s disease
Amyloid-β
Cerebrovascular disease
Lipid metabolism
Longevity
Online Access:http://link.springer.com/article/10.1186/s13024-020-00413-4

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http://link.springer.com/article/10.1186/s13024-020-00413-4

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