Molecular target mechanisms of celecoxib induced liver damage in rats and the potential prophylactic roles of melatonin and/or quercetin

Molecular target mechanisms of celecoxib induced liver damage in rats and the potential prophylactic roles of melatonin and/or quercetin

Context: Celecoxib (Cele), a nonsteroidal anti-inflammatory drug (NSAID) is linked with a spectrum of hepatotoxic influences, however the underlying mechanism (s) by which this drug induces liver damage is still unexplored. Aims: To demonstrate the hepatotoxic mechanism (s) of Cele in rats and th...

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Bibliographic Details
Main Authors: Emtenan Sami Sulimani, Jehad Mustafa Yousef, Azza M. Mohamed
Format: Article
Language:English
Published: Academic Association of Pharmaceutical Sciences from Antofagasta (ASOCIFA) 2021-07-01
Series:Journal of Pharmacy & Pharmacognosy Research
Subjects:
celecoxib
inflammation
liver
melatonin
oxidative stress
quercetin
Online Access:https://jppres.com/jppres/pdf/vol9/jppres20.976_9.4.397.pdf

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https://jppres.com/jppres/pdf/vol9/jppres20.976_9.4.397.pdf

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