Cyclic Peptide-Based Biologics Regulating HGF-MET

Cyclic Peptide-Based Biologics Regulating HGF-MET

Using a random non-standard peptide integrated discovery system, we obtained cyclic peptides that bind to hepatocyte growth factor (HGF) or mesenchymal-epithelial transition factor. (MET) HGF-inhibitory peptide-8 (HiP-8) selectively bound to two-chain active HGF, but not to single-chain precursor HG...

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Bibliographic Details
Main Authors: Hiroki Sato, Ryu Imamura, Hiroaki Suga, Kunio Matsumoto, Katsuya Sakai
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
atomic force microscopy
cyclic peptide
HGF
MET
MET agonist
PET imaging
Online Access:https://www.mdpi.com/1422-0067/21/21/7977

Internet

https://www.mdpi.com/1422-0067/21/21/7977

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