N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase

N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase

Breakdown of neuro-glial N-acetyl-aspartate (NAA) metabolism results in the failure of developmental myelination, manifest in the congenital pediatric leukodystrophy Canavan disease caused by mutations to the sole NAA catabolizing enzyme aspartoacylase. Canavan disease is a major point of focus for...

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Bibliographic Details
Main Authors: Jeremy S. Francis, PhD, Ireneusz Wojtas, PhD, Vladimir Markov, MD, Steven J. Gray, PhD, Thomas J. McCown, PhD, R. Jude Samulski, PhD, Larissa T. Bilaniuk, MD, Dah-Jyuu Wang, PhD, Darryl C. De Vivo, MD, Christopher G. Janson, MD, Paola Leone, PhD
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Neurobiology of Disease
Subjects:
N-acetylaspartate
Aspartoacylase
Canavan disease
Myelination
Energy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116302340

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http://www.sciencedirect.com/science/article/pii/S0969996116302340

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