Cholesterol content in cell membrane maintains surface levels of ErbB2 and confers a therapeutic vulnerability in ErbB2-positive breast cancer

Cholesterol content in cell membrane maintains surface levels of ErbB2 and confers a therapeutic vulnerability in ErbB2-positive breast cancer

Abstract Background ErbB2 overexpression identifies a subset of breast cancer as ErbB2-positive and is frequently associated with poor clinical outcomes. As a membrane-embedded receptor tyrosine kinase, cell surface levels of ErbB2 are regulated dynamically by membrane physical properties. The prese...

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Bibliographic Details
Main Authors: Jinrui Zhang, Qiong Li, Yueguang Wu, Duchuang Wang, Lu Xu, Yang Zhang, Shanshan Wang, Taishu Wang, Fang Liu, Mohamed Y. Zaky, Shuai Hou, Shuyan Liu, Kun Zou, Haixin Lei, Lijuan Zou, Yingqiu Zhang, Han Liu
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Cell Communication and Signaling
Subjects:
ErbB2
Breast cancer
Cholesterol
Membrane fluidity
Membrane rigidity
Lovastatin
Online Access:http://link.springer.com/article/10.1186/s12964-019-0328-4

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http://link.springer.com/article/10.1186/s12964-019-0328-4

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