Suppressing miR-199a-3p by promoter methylation contributes to tumor aggressiveness and cisplatin resistance of ovarian cancer through promoting DDR1 expression

Suppressing miR-199a-3p by promoter methylation contributes to tumor aggressiveness and cisplatin resistance of ovarian cancer through promoting DDR1 expression

Abstract Background Discoidin Domain Receptor 1 (DDR1) belongs to the family of collagen receptor tyrosine kinases that confers the progression of various cancers. Aberrant expression of DDR1 was detected in several human cancers including ovarian cancer, which had been shown to increase the migrati...

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Bibliographic Details
Main Authors: Yuao Deng, Fang Zhao, Liu Hui, Xiuyun Li, Danyu Zhang, Wang Lin, Zhiqiang Chen, Yingxia Ning
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Journal of Ovarian Research
Subjects:
Ovarian cancer
miR-199a-3p
Discoidin domain receptor 1 (DDR1)
Cisplatin
Online Access:http://link.springer.com/article/10.1186/s13048-017-0333-4

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http://link.springer.com/article/10.1186/s13048-017-0333-4

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