Histamine H3 Receptor Signaling Regulates the NLRP3 Inflammasome Activation in C2C12 Myocyte During Myogenic Differentiation

Histamine H3 Receptor Signaling Regulates the NLRP3 Inflammasome Activation in C2C12 Myocyte During Myogenic Differentiation

NLRP3 inflammasome has been implicated in impaired post-injury muscle healing and in muscle atrophy. Histamine receptors play an important role in inflammation, but the role of histamine H3 receptor (H3R) in myocyte regeneration and in the regulation of NLRP3 inflammasome is not known. We studied th...

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Bibliographic Details
Main Authors: Yan Chen, Yuan Ma, Jin Jin Feng, Yi He Wang, Tian Fang Li, Katariina Nurmi, Kari K. Eklund, Jian Guo Wen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
histamine H3 receptor
myogenesis
inflammation
NLRP3 inflammasome
IL-1β
TNFα
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.599393/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.599393/full

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