Unraveling the mechanism of the cadherin-catenin-actin catch bond.

The adherens junctions between epithelial cells involve a protein complex formed by E-cadherin, β-catenin, α-catenin and F-actin. The stability of this complex was a puzzle for many years, since in vitro studies could reconstitute various stable subsets of the individual proteins, but never the enti...

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Bibliographic Details
Main Authors: Shishir Adhikari, Jacob Moran, Christopher Weddle, Michael Hinczewski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-08-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC6114904?pdf=render