A novel synthesis of 2,5-di-substituted pyridine derivatives by the ring opening and closing cascade (ROCC) mechanism

A novel synthesis of 2,5-di-substituted pyridine derivatives by the ring opening and closing cascade (ROCC) mechanism

A new regioselective method for the synthesis of 2-aryl-5-benzoylpyridine derivatives has been developed. The reaction proceeds via ring opening and closing cascade mechanism (ROCC) of isoxazole to synthesize various functionalized pyridine derivatives. This is the first report for the preparation o...

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Main Authors: K. Raghavulu, M. Sambaiah, Ramakrishna Gudipati, K. Basavaiah, Satyanarayana Yennam, Manoranjan Behera
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Journal of Saudi Chemical Society
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610319300559
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spelling doaj-365c89e3f9544c32a43603b04233d7a52020-11-25T01:13:36ZengElsevierJournal of Saudi Chemical Society1319-61032019-12-0123810241031A novel synthesis of 2,5-di-substituted pyridine derivatives by the ring opening and closing cascade (ROCC) mechanismK. Raghavulu0M. Sambaiah1Ramakrishna Gudipati2K. Basavaiah3Satyanarayana Yennam4Manoranjan Behera5Chemistry Services, GVK Biosciences Pvt. Ltd., Survey No: 125 (part) & 126, IDA Mallapur, Hyderabad 500076, Telangana State, India; Department of Inorganic & Analytical Chemistry, Andhra University, Waltair Junction, Visakhapatnam, Andhra Pradesh 530003, IndiaChemistry Services, GVK Biosciences Pvt. Ltd., Survey No: 125 (part) & 126, IDA Mallapur, Hyderabad 500076, Telangana State, IndiaChemistry Services, GVK Biosciences Pvt. Ltd., Survey No: 125 (part) & 126, IDA Mallapur, Hyderabad 500076, Telangana State, India; Department of Inorganic & Analytical Chemistry, Andhra University, Waltair Junction, Visakhapatnam, Andhra Pradesh 530003, IndiaDepartment of Inorganic & Analytical Chemistry, Andhra University, Waltair Junction, Visakhapatnam, Andhra Pradesh 530003, IndiaChemistry Services, GVK Biosciences Pvt. Ltd., Survey No: 125 (part) & 126, IDA Mallapur, Hyderabad 500076, Telangana State, IndiaChemistry Services, GVK Biosciences Pvt. Ltd., Survey No: 125 (part) & 126, IDA Mallapur, Hyderabad 500076, Telangana State, India; Corresponding author.A new regioselective method for the synthesis of 2-aryl-5-benzoylpyridine derivatives has been developed. The reaction proceeds via ring opening and closing cascade mechanism (ROCC) of isoxazole to synthesize various functionalized pyridine derivatives. This is the first report for the preparation of 2,5-di-substituted pyridines using Fe/NH4Cl as a reducing reagent. Keywords: Isoxazole, 2,5-Disubstituted pyridines, ROCC mechanism, Fe/NH4Clhttp://www.sciencedirect.com/science/article/pii/S1319610319300559
collection DOAJ
language English
format Article
sources DOAJ
author K. Raghavulu
M. Sambaiah
Ramakrishna Gudipati
K. Basavaiah
Satyanarayana Yennam
Manoranjan Behera
spellingShingle K. Raghavulu
M. Sambaiah
Ramakrishna Gudipati
K. Basavaiah
Satyanarayana Yennam
Manoranjan Behera
A novel synthesis of 2,5-di-substituted pyridine derivatives by the ring opening and closing cascade (ROCC) mechanism
Journal of Saudi Chemical Society
author_facet K. Raghavulu
M. Sambaiah
Ramakrishna Gudipati
K. Basavaiah
Satyanarayana Yennam
Manoranjan Behera
author_sort K. Raghavulu
title A novel synthesis of 2,5-di-substituted pyridine derivatives by the ring opening and closing cascade (ROCC) mechanism
title_short A novel synthesis of 2,5-di-substituted pyridine derivatives by the ring opening and closing cascade (ROCC) mechanism
title_full A novel synthesis of 2,5-di-substituted pyridine derivatives by the ring opening and closing cascade (ROCC) mechanism
title_fullStr A novel synthesis of 2,5-di-substituted pyridine derivatives by the ring opening and closing cascade (ROCC) mechanism
title_full_unstemmed A novel synthesis of 2,5-di-substituted pyridine derivatives by the ring opening and closing cascade (ROCC) mechanism
title_sort novel synthesis of 2,5-di-substituted pyridine derivatives by the ring opening and closing cascade (rocc) mechanism
publisher Elsevier
series Journal of Saudi Chemical Society
issn 1319-6103
publishDate 2019-12-01
description A new regioselective method for the synthesis of 2-aryl-5-benzoylpyridine derivatives has been developed. The reaction proceeds via ring opening and closing cascade mechanism (ROCC) of isoxazole to synthesize various functionalized pyridine derivatives. This is the first report for the preparation of 2,5-di-substituted pyridines using Fe/NH4Cl as a reducing reagent. Keywords: Isoxazole, 2,5-Disubstituted pyridines, ROCC mechanism, Fe/NH4Cl
url http://www.sciencedirect.com/science/article/pii/S1319610319300559
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