Probing RNA Conformational Equilibria within the Functional Cellular Context

Summary: Low-abundance short-lived non-native conformations referred to as excited states (ESs) are increasingly observed in vitro and implicated in the folding and biological activities of regulatory RNAs. We developed an approach for assessing the relative abundance of RNA ESs within the functiona...

Full description

Bibliographic Details
Main Authors: Laura R. Ganser, Chia-Chieh Chu, Hal P. Bogerd, Megan L. Kelly, Bryan R. Cullen, Hashim M. Al-Hashimi
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720301583