Behavioral decline and premature lethality upon pan-neuronal ferritin overexpression in Drosophila infected with a virulent form of Wolbachia.

Behavioral decline and premature lethality upon pan-neuronal ferritin overexpression in Drosophila infected with a virulent form of Wolbachia.

Iron is required for organismal growth. Therefore, limiting iron availability may be a key part of the host’s innate immune response to various pathogens, for example in Drosophila infected with Zygomycetes. One way the host can transiently reduce iron bioavailability is by ferritin overexpression....

Full description

Bibliographic Details
Main Authors: Stylianos eKosmidis, Fanis eMissirlis, Jose A. Botella, Stephan eSchneuwly, Tracey A. Rouault, Efthimios M. C. Skoulakis
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Pharmacology
Subjects:
Aging
Immunity
Rickettsia
Symbiosis
insect
neurodegeneration
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00066/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00066/full

Similar Items