The critical role of dysregulated Hh-FOXM1-TPX2 signaling in human hepatocellular carcinoma cell proliferation

The critical role of dysregulated Hh-FOXM1-TPX2 signaling in human hepatocellular carcinoma cell proliferation

Abstract Background Aberrant activation of the Hedgehog (Hh) signaling pathway is frequently observed in hepatocellular carcinoma (HCC), nevertheless, the precise molecular mechanism remains unclear. Forkhead box M1 (FOXM1), a target of the Hh pathway, is a key oncofetal transcription factor and a m...

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Main Authors: Yiting Wang, Hailong Wang, Zhengwei Yan, Guohua Li, Guohui Hu, Hong Zhang, Dengliang Huang, Yao Wang, Xiang Zhang, Yehong Yan, Quqin Lu, Minzhang Cheng, Shiwen Luo
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Cell Communication and Signaling
Subjects:
Hepatocellular carcinoma
Hedgehog signaling pathway
FOXM1
TPX2
Proliferation
Online Access:http://link.springer.com/article/10.1186/s12964-020-00628-4

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http://link.springer.com/article/10.1186/s12964-020-00628-4

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