Podophyllotoxin and Rutin Modulate M1 (iNOS+) Macrophages and Mitigate Lethal Radiation (LR) Induced Inflammatory Responses in Mice

Podophyllotoxin and Rutin Modulate M1 (iNOS+) Macrophages and Mitigate Lethal Radiation (LR) Induced Inflammatory Responses in Mice

Accidental exposure to lethal doses of Gamma radiation leads to the systemic inflammatory syndrome which causes mortality. In view of this, management of hemopoietic syndrome by modulating pro-inflammatory response in clinically manageable time period seems to be the most appropriate strategy for en...

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Bibliographic Details
Main Authors: Vinod Nadella, Rajiv Ranjan, Balasubramanian Senthilkumaran, S. S. Y. H. Qadri, Suresh Pothani, Ajay Kumar Singh, Manju L. Gupta, Hridayesh Prakash
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
radiation syndrome
macrophages polarization
Th1/2 response
immune tolerance
radioprotection
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00106/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00106/full

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