Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models

Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models

Prion diseases are a group of infectious diseases characterized by multiple neuropathological changes, yet the mechanisms that preserve function and protect against prion-associated neurodegeneration are still unclear. We previously reported that the repressor element 1-silencing transcription facto...

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Bibliographic Details
Main Authors: Zhiqi Song, Syed Z. A. Shah, Wei Yang, Haodi Dong, Lifeng Yang, Xiangmei Zhou, Deming Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
RE1-silencing transcription factor
prion diseases
neuroprotective mechanism
the Akt–mTOR signaling
the Wnt-β-catenin signaling
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00128/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00128/full

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