Quantitative Proteomic Analysis in Alveolar Type II Cells Reveals the Different Capacities of RAS and TGF-β to Induce Epithelial–Mesenchymal Transition

Quantitative Proteomic Analysis in Alveolar Type II Cells Reveals the Different Capacities of RAS and TGF-β to Induce Epithelial–Mesenchymal Transition

Alveolar type II (ATII) epithelial cells function as stem cells, contributing to alveolar renewal, repair and cancer. Therefore, they are a highly relevant model for studying a number of lung diseases, including acute injury, fibrosis and cancer, in which signals transduced by RAS and transforming g...

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Bibliographic Details
Main Authors: Yilu Zhou, Charlotte Hill, Liudi Yao, Juanjuan Li, David Hancock, Julian Downward, Mark G. Jones, Donna E. Davies, Rob M. Ewing, Paul Skipp, Yihua Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
epithelial-mesenchymal transition (EMT)
RAS
TGF-β
lung disease
fibrosis
proteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.595712/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.595712/full

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