Role of 2-Arachidonoyl-Glycerol and CB1 Receptors in Orexin-A-Mediated Prevention of Oxygen–Glucose Deprivation-Induced Neuronal Injury

Role of 2-Arachidonoyl-Glycerol and CB1 Receptors in Orexin-A-Mediated Prevention of Oxygen–Glucose Deprivation-Induced Neuronal Injury

Orexin-A (OX-A) protects the brain against oxidative stress-mediated ischemic injury. Since the endocannabinoid 2-arachidonoylglycerol (2-AG) and cannabinoid type-1 (CB1) receptors were previously shown to mediate some of the effects of OX-A exerted through the orexin-1 receptor (OX-1R), we investig...

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Bibliographic Details
Main Authors: Letizia Palomba, Andrea Motta, Roberta Imperatore, Fabiana Piscitelli, Raffaele Capasso, Federica Mastroiacovo, Giuseppe Battaglia, Valeria Bruno, Luigia Cristino, Vincenzo Di Marzo
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cells
Subjects:
endocannabinoids
orexin-A
oxygen–glucose deprivation
ischemia
radical oxygen species
neuronal cell death
Online Access:https://www.mdpi.com/2073-4409/9/6/1507

Internet

https://www.mdpi.com/2073-4409/9/6/1507

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