Pharmacokinetic and Pharmacodynamic Integration and Resistance Analysis of Tilmicosin Against Mycoplasma gallisepticum in an In Vitro Dynamic Model

Pharmacokinetic and Pharmacodynamic Integration and Resistance Analysis of Tilmicosin Against Mycoplasma gallisepticum in an In Vitro Dynamic Model

Mycoplasma gallisepticum is the major pathogen causing chronic respiratory disease in chickens. In the present study, we successfully established a one-compartment open model with first-order absorption to determine the relationship between tilmicosin pharmacokinetic and pharmacodynamic (PK/PD) indi...

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Bibliographic Details
Main Authors: Zilong Huang, Yuzhi Wu, Zichong Zhou, Xirui Xia, Xiaoyan Gu, Qinren Cai, Xiangguang Shen, Hong Yang, Huanzhong Ding
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Pharmacology
Subjects:
tilmicosin
Mycoplasma gallisepticum
dynamic model
pharmacokinetics
pharmacodynamics
resistance
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00670/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00670/full

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