Use of Multivariable Mendelian Randomization to Address Biases Due to Competing Risk Before Recruitment

Use of Multivariable Mendelian Randomization to Address Biases Due to Competing Risk Before Recruitment

Background: Mendelian randomization (MR) provides unconfounded estimates. MR is open to selection bias when the underlying sample is selected on surviving to recruitment on the genetically instrumented exposure and competing risk of the outcome. Few methods to address this bias exist.Methods: We sho...

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Bibliographic Details
Main Authors: C. M. Schooling, P. M. Lopez, Z. Yang, J. V. Zhao, Shiu Lun Au Yeung, Jian V. Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Genetics
Subjects:
selection bias
competing risk
Mendelian randomization
shared etiology
instrumental variable analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2020.610852/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2020.610852/full

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