Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone.

Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone.

The cytokine receptor activator of nuclear factor kappa B ligand (RANKL), encoded by the Tnfsf11 gene, is essential for osteoclastogenesis and previous studies have shown that deletion of the Tnfsf11 gene using a Dmp1-Cre transgene reduces osteoclast formation in cancellous bone by more than 70%. Ho...

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Bibliographic Details
Main Authors: Jinhu Xiong, Marilina Piemontese, Melda Onal, Josh Campbell, Joseph J Goellner, Vladimir Dusevich, Lynda Bonewald, Stavros C Manolagas, Charles A O'Brien
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4578942?pdf=render

Internet

http://europepmc.org/articles/PMC4578942?pdf=render

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