Design of multi-specificity in protein interfaces.

Interactions in protein networks may place constraints on protein interface sequences to maintain correct and avoid unwanted interactions. Here we describe a "multi-constraint" protein design protocol to predict sequences optimized for multiple criteria, such as maintaining sets of interac...

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Bibliographic Details
Main Authors: Elisabeth L Humphris, Tanja Kortemme
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-08-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.0030164