Opioid Actions in Primary-Afferent Fibers—Involvement in Analgesia and Anesthesia

Opioid Actions in Primary-Afferent Fibers—Involvement in Analgesia and Anesthesia

Opioids inhibit glutamatergic excitatory transmission from the periphery by activating G-protein coupled opioid receptors in the central terminals of primary-afferent neurons in the spinal substantia gelatinosa, resulting in antinociception. Opioid receptor activation in the peripheral terminals of...

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Bibliographic Details
Main Authors: Tsugumi Fujita, Kotaro Mizuta, Eiichi Kumamoto
Format: Article
Language:English
Published: MDPI AG 2011-01-01
Series:Pharmaceuticals
Subjects:
opioids
spinal dorsal horn
excitatory synaptic transmission
primary-afferent fiber
action potential conduction
Online Access:http://www.mdpi.com/1424-8247/4/2/343/

Internet

http://www.mdpi.com/1424-8247/4/2/343/

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