5′-upstream variants of CRHR1 and MAPT genes associated with age at onset in progressive supranuclear palsy and cortical basal degeneration

5′-upstream variants of CRHR1 and MAPT genes associated with age at onset in progressive supranuclear palsy and cortical basal degeneration

Two different H1 sub-haplotypes at chromosome 17q21, H1C and H1E′A, have been associated with progressive supranuclear palsy (PSP) and cortical basal degeneration (CBD). We analyzed the SNPs included in the H1C and H1E′A haplotypes in a large Spanish PSP/CBD series and their interaction with age at...

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Bibliographic Details
Main Authors: Carlos Cruchaga, Jose M. Vidal-Taboada, Mario Ezquerra, Elena Lorenzo, Pablo Martinez-Lage, Marta Blazquez, Eduardo Tolosa, Pau Pastor
Format: Article
Language:English
Published: Elsevier 2009-02-01
Series:Neurobiology of Disease
Subjects:
Progressive supranuclear palsy
Cortical basal degeneration
Microtubule-associated protein tau
Haplotype
Age at onset
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108002490

Internet

http://www.sciencedirect.com/science/article/pii/S0969996108002490

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