Pharmacologic Approach to Defective Protein Trafficking in the E637K-hERG Mutant with PD-118057 and Thapsigargin.

Pharmacologic Approach to Defective Protein Trafficking in the E637K-hERG Mutant with PD-118057 and Thapsigargin.

Treatment of LQT2 is inadequate. Many drugs which can pharmacologically rescue defective protein trafficking in LQT2 also result in potent blockade of HERG current, negating their therapeutic benefit. It is reported that PD-118057 and thapsigargin can rescue LQT2 without hERG channel blockade, but t...

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Bibliographic Details
Main Authors: Haiyan Mao, Xiaoli Lu, Justin Michael Karush, Xiaoyan Huang, Xi Yang, Yanna Ba, Ying Wang, Ningsheng Liu, Jianqing Zhou, Jiangfang Lian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3686757?pdf=render

Internet

http://europepmc.org/articles/PMC3686757?pdf=render

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