Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys

Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys

<p>Abstract</p> <p>Background</p> <p>Anti-IL-21R antibodies are potential therapeutics for the treatment of autoimmune diseases. This study evaluated correlations between the pharmacodynamic (PD) activity, pharmacokinetics, and anti-product antibody responses of human a...

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Bibliographic Details
Main Authors: Spaulding Vikki, Ma Margery, Ryan Mark, Bree Andrea, Szklut Pamela, Allen Scott, Vugmeyster Yulia, Young Deborah, Guay Heath, Bloom Laird, Leach Michael W, O'Toole Margot, Adkins Karissa
Format: Article
Language:English
Published: BMC 2010-04-01
Series:Journal of Translational Medicine
Online Access:http://www.translational-medicine.com/content/8/1/41

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http://www.translational-medicine.com/content/8/1/41

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