Vaccinium bracteatum Leaf Extract Reverses Chronic Restraint Stress-Induced Depression-Like Behavior in Mice: Regulation of Hypothalamic-Pituitary-Adrenal Axis, Serotonin Turnover Systems, and ERK/Akt Phosphorylation

Vaccinium bracteatum Leaf Extract Reverses Chronic Restraint Stress-Induced Depression-Like Behavior in Mice: Regulation of Hypothalamic-Pituitary-Adrenal Axis, Serotonin Turnover Systems, and ERK/Akt Phosphorylation

The leaves of Vaccinium bracteatum Thunb. are a source of traditional herbal medicines found in East Asia. The present study aimed to evaluate the mechanisms underlying the antidepressant-like effects of water extract of V. bracteatum Thunb. leaves (VBLW) in a mouse model of chronic restraint stress...

Full description

Bibliographic Details
Main Authors: Dool-Ri Oh, Ji-Seok Yoo, Yujin Kim, Huwon Kang, Hunmi Lee, So J. Lm, Eun-jin Choi, Myung-A Jung, Donghyuck Bae, Kyo-Nyeo Oh, Ji-Ae Hong, Ara Jo, Jawon Shin, Jaeyong Kim, Young R. Kim, Seung S. Cho, Beom-Jin Lee, Chul yung Choi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
Vaccinium bracteatum Thunb.
antidepressants
neuroprotection
chronic restraint stress
corticosterone
HPA axis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00604/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00604/full

Similar Items