WBC count and functional changes induced by co-administration of clofazimine and clarithromycin, in single and multiple doses, in Wistar rats

WBC count and functional changes induced by co-administration of clofazimine and clarithromycin, in single and multiple doses, in Wistar rats

Clofazimine and clarithromycin are used to treat leprosy and infections caused by Mycobacterium avium complex. Little data on the toxicity of co-administration of these two drugs are available. Here we evaluated the potential adverse effects of polytherapy with these two drugs in male Wistar rats by...

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Bibliographic Details
Main Authors: Flávia Aparecida Paina, Julise Cunha Miranda, Cristiane Fernandes de Freitas Tavares, Regina Helena da Costa Queiroz, Ana Maria de Souza
Format: Article
Language:English
Published: Universidade de São Paulo 2012-09-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Clofazimina
Claritromicina
Hanseníase
Mycobacterium avium
Leucócitos
Fagocitose
Burst oxidativo
Clofazimine
Clarithromycin
Leprosy
Leukocytes
Phagocytosis
Oxidative burst
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000300008

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000300008

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