1H-NMR and MALDI-TOF MS as metabolomic quality control tests to classify platelet derived medium additives for GMP compliant cell expansion procedures.

1H-NMR and MALDI-TOF MS as metabolomic quality control tests to classify platelet derived medium additives for GMP compliant cell expansion procedures.

INTRODUCTION:Ex vivo cell expansion under Good Manufacturing Practice (GMP) guidelines can be performed using medium additives containing human growth factors from platelets. These products can differently affect proliferation of adipose mesenchymal stromal stem cells (ASC). Qualification of medium...

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Bibliographic Details
Main Authors: Francesco Agostini, Marta Ruzza, Davide Corpillo, Luca Biondi, Elena Acquadro, Barbara Canepa, Alessandra Viale, Monica Battiston, Fabrizio Serra, Silvio Aime, Mario Mazzucato
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6126812?pdf=render

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http://europepmc.org/articles/PMC6126812?pdf=render

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