The eroding chromatin landscape of aging stem cells

The eroding chromatin landscape of aging stem cells

Adult stem cells undergo both replicative and chronological aging in their niches, with catastrophic declines in regenerative potential with age. Due to repeated environmental insults during aging, the chromatin landscape of stem cells erodes, with changes in both DNA and histone modifications, accu...

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Bibliographic Details
Main Authors: Changyou Shi, Lin Wang, Payel Sen
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2020-01-01
Series:Translational Medicine of Aging
Subjects:
Stem cell
Aging
Self-renewal
Differentiation
Epigenetics/chromatin
Online Access:http://www.sciencedirect.com/science/article/pii/S2468501120300195
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spelling doaj-35b4dda9a261493f802b66caded2957a2021-04-02T16:37:05ZengKeAi Communications Co., Ltd.Translational Medicine of Aging2468-50112020-01-014121131The eroding chromatin landscape of aging stem cells Changyou Shi0Lin Wang1Payel Sen2Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USALaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USACorresponding author.; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USAAdult stem cells undergo both replicative and chronological aging in their niches, with catastrophic declines in regenerative potential with age. Due to repeated environmental insults during aging, the chromatin landscape of stem cells erodes, with changes in both DNA and histone modifications, accumulation of damage, and altered transcriptional response. A body of work has shown that altered chromatin is a driver of cell fate changes and a regulator of self-renewal in stem cells and therefore a prime target for juvenescence therapeutics. This review focuses on chromatin changes in stem cell aging and provides a composite view of both common and unique epigenetic themes apparent from the studies of multiple stem cell types.http://www.sciencedirect.com/science/article/pii/S2468501120300195Stem cellAgingSelf-renewalDifferentiationEpigenetics/chromatin
collection DOAJ
language English
format Article
sources DOAJ
author Changyou Shi
Lin Wang
Payel Sen
spellingShingle Changyou Shi
Lin Wang
Payel Sen
The eroding chromatin landscape of aging stem cells
Translational Medicine of Aging
Stem cell
Aging
Self-renewal
Differentiation
Epigenetics/chromatin
author_facet Changyou Shi
Lin Wang
Payel Sen
author_sort Changyou Shi
title The eroding chromatin landscape of aging stem cells
title_short The eroding chromatin landscape of aging stem cells
title_full The eroding chromatin landscape of aging stem cells
title_fullStr The eroding chromatin landscape of aging stem cells
title_full_unstemmed The eroding chromatin landscape of aging stem cells
title_sort eroding chromatin landscape of aging stem cells
publisher KeAi Communications Co., Ltd.
series Translational Medicine of Aging
issn 2468-5011
publishDate 2020-01-01
description Adult stem cells undergo both replicative and chronological aging in their niches, with catastrophic declines in regenerative potential with age. Due to repeated environmental insults during aging, the chromatin landscape of stem cells erodes, with changes in both DNA and histone modifications, accumulation of damage, and altered transcriptional response. A body of work has shown that altered chromatin is a driver of cell fate changes and a regulator of self-renewal in stem cells and therefore a prime target for juvenescence therapeutics. This review focuses on chromatin changes in stem cell aging and provides a composite view of both common and unique epigenetic themes apparent from the studies of multiple stem cell types.
topic Stem cell
Aging
Self-renewal
Differentiation
Epigenetics/chromatin
url http://www.sciencedirect.com/science/article/pii/S2468501120300195
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