Metformin Suppresses Cancer Stem Cells through AMPK Activation and Inhibition of Protein Prenylation of the Mevalonate Pathway in Colorectal Cancer

Metformin Suppresses Cancer Stem Cells through AMPK Activation and Inhibition of Protein Prenylation of the Mevalonate Pathway in Colorectal Cancer

Metformin is a well-known AMPK (AMP-activated protein kinase) activator that suppresses cancer stem cells (CSCs) in some cancers. However, the mechanisms of the CSC-suppressing effects of metformin are not yet well understood. In this study, we investigated the CSC-suppressive effect of metformin vi...

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Bibliographic Details
Main Authors: Yoojeong Seo, Janghyun Kim, Soo Jung Park, Jae Jun Park, Jae Hee Cheon, Won Ho Kim, Tae Il Kim
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
cancer stem cells
metformin
mevalonate pathway
protein prenylation
colorectal cancer
Online Access:https://www.mdpi.com/2072-6694/12/9/2554

Internet

https://www.mdpi.com/2072-6694/12/9/2554

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