Repeat‐associated non‐AUG translation in C9orf72‐ALS/FTD is driven by neuronal excitation and stress

Repeat‐associated non‐AUG translation in C9orf72‐ALS/FTD is driven by neuronal excitation and stress

Abstract Nucleotide repeat expansions (NREs) are prevalent mutations in a multitude of neurodegenerative diseases. Repeat‐associated non‐AUG (RAN) translation of these repeat regions produces mono or dipeptides that contribute to the pathogenesis of these diseases. However, the mechanisms and driver...

Full description

Bibliographic Details
Main Authors: Thomas Westergard, Kevin McAvoy, Katelyn Russell, Xinmei Wen, Yu Pang, Brandie Morris, Piera Pasinelli, Davide Trotti, Aaron Haeusler
Format: Article
Language:English
Published: Wiley 2019-02-01
Series:EMBO Molecular Medicine
Subjects:
ALS
C9orf72
DPR
excitotoxicity
FTD
Online Access:https://doi.org/10.15252/emmm.201809423

Internet

https://doi.org/10.15252/emmm.201809423

Similar Items