Clinico-pathological associations and concomitant mutations of the RAS/RAF pathway in metastatic colorectal cancer

Clinico-pathological associations and concomitant mutations of the RAS/RAF pathway in metastatic colorectal cancer

Abstract Background Over the past few years, next-generation sequencing (NGS) has become reliable and cost-effective, and its use in clinical practice has become a reality. A relevant role for NGS is the prediction of response to anti-EGFR agents in metastatic colorectal cancer (mCRC), where multipl...

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Bibliographic Details
Main Authors: Edoardo Isnaldi, Anna Garuti, Gabriella Cirmena, Stefano Scabini, Edoardo Rimini, Lorenzo Ferrando, Michela Lia, Roberto Murialdo, Lucia Tixi, Enrico Carminati, Andrea Panaro, Maurizio Gallo, Federica Grillo, Luca Mastracci, Lazzaro Repetto, Roberto Fiocca, Emanuele Romairone, Gabriele Zoppoli, Alberto Ballestrero
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Translational Medicine
Subjects:
Metastatic colorectal cancer
Extended RAS
RAS/RAF pathway
Anti-EGFR
Concomitant mutations
Online Access:http://link.springer.com/article/10.1186/s12967-019-1879-2

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http://link.springer.com/article/10.1186/s12967-019-1879-2

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